CURRICULUM VITAE
St. Thomas University
School of Science, Technology and Engineering Management
16401 NW 37th Avenue, Carnival Building, Room 215
Miami Gardens, FL 33054
(305) 628-6538
Email: atapanes-castillo@stu.edu
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BIOGRAPHICAL SKETCH
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NAME
Tapanes-Castillo, Alexis
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POSITION TITLE
Research Assistant Professor of Biology
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BIRTHDATE
9/15/1976
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EDUCATION/TRAINING
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INSTITUTION AND LOCATION
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DEGREE
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YEAR
CONFERRED
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FIELD OF STUDY
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University of Miami, Coral Gables, FL
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BS
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1998
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Biology
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Cornell University Weill Graduate School of Medical Sciences, New York, NY
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PhD
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2004
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Molecular Biology
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Marine Biological Laboratory, Woods Hole, MA
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Certificate
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2004
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Embryology
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University of Miami Miller School of Medicine, Miami, FL
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Postdoctoral
training
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2004-2009
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Developmental Neuroscience, Genetics
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A. Research Experience
1998-2004 Graduate Research Assistant, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, Laboratory of Dr. Mary K. Baylies, New York, NY. Doctoral thesis: Notch signaling and the patterning of Drosophila mesodermal segments.
2004 Embryology: Concepts and Techniques in Modern Developmental Biology course,
Marine Biological Laboratory, Woods Hole, MA.
2004-2009 Postdoctoral Associate/Fellow/Scholar, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Laboratory of Dr. John L. Bixby and Dr. Vance P. Lemmon, Miami, FL. Projects: (1) Mapping modifier loci that contribute to L1 cell adhesion molecule X-linked hydrocephalus, (2) A high content screen for bioactive compounds that regulate cell adhesion molecule (CAM)-mediated neuronal morphogenesis. (3) Hedgehog signaling regulates CAM- mediated neuronal morphogenesis.
2008 Genetic analysis of complex human diseases course, Miami, FL.
2009-present Research Assistant Professor in Biology, St. Thomas University, Miami Gardens,FL. Projects: (1) Determinants fundamental to axon regeneration in zebrafish (Department of Defense grant # W81XWH-09-1-0403 awarded to Dr. J. Plunkett), (2) Identification and characterization of the hydrocephalus-associated locus within L1cam hydrocephalus modifier 1
Instructor: Biochemistry II (BIO 353), Biochemistry II Laboratory (BIO 353L),
Cell Biology Laboratory (330L), Microbiology Laboratory (BIO 325), Senior Research Seminar (BIO 491)
B. Honors
1998 Magna Cum Laude, General Honors, Departmental Honors in Biology, Phi Beta Kappa,
University of Miami, Coral Gables, FL.
1998 NIH Predoctoral training grant T32-GM08539, Cornell University, New York, NY.
2004 American Society for Cell Biology and William Townsend Porter scholarships, Marine
Biological Laboratory, Woods Hole, MA.
2004 NIH Facilities of Research Excellence in Spinal Cord Injury (FORE-SCI) postdoctoral training
grant N01-NS-3-2351, University of Miami Miller School of Medicine, Miami, FL.
2006 Gordon Research Conference Carl Storm Underrepresented Minority Fellowship, Mt. Holyoke,
MA.
2007 NIH postdoctoral training grantT32-GM08539, University of Miami Miller School of Medicine, Miami,FL.
C. Publications
Peer-reviewed journal articles
Tapanes-Castillo, A. and Baylies, M.K. (2004) Notch signaling patterns Drosophila mesodermal segments by regulating the bHLH transcription factor Twist. Development 131, 2359-2372.
Tapanes-Castillo, A., Weaver, E.J., Smith, R.P., Kamei, Y., Caspary, T., Hamilton-Nelson, K.L.,
Slifer, S.H.,Martin, E.R., Bixby, J.L. and Lemmon, V.P. (2010) A modifier locus on chromosome 5
contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice. Neurogenetics 11 (1),
53-71.
Book chapter
Tapanes-Castillo, A., Cox, V. and Baylies, M.K. (2004) Conserved and divergent roles of Twist in gastrulation. In: Gastrulation: From Cells to Embryos, (ed. C.D. Stern), New York: Cold Spring Harbor Laboratory Press, 619-629.
Selected Poster Presentations
Tapanes-Castillo, A. and M.K. Baylies. (2001) An early role for Notch that represses Drosophila
myogenesis.(2001) 42nd Annual Drosophila Research Conference, poster 688A, Pittsburgh, PA.
Tapanes-Castillo, A. and Baylies, M.K. (2002) Notch signaling regulates mesoderm subdivision in Drosophila by inhibiting Twist. Northeast Regional Meeting of the Society for Developmental Biology, poster, Woods Hole, MA
Tapanes-Castillo, A. and M.K. Baylies. (2003) Regulation of a mesodermal bHLH network by Notch signaling. 44th Annual Drosophila Research Conference, poster 341B, Chicago, IL.
Tapanes-Castillo, A.,Bixby, J.L. and Lemmon,V.P. (2005) Mechanisms of CAM regulated neuronal morphogenesis. Society for Neuroscience Annual Meeting, poster 249.7, Washington, D.C.
Tapanes-Castillo, A., Bixby, J.L. and Lemmon, V.P. (2006) A high content screen for bioactive
compounds that regulate CAM mediated neuronal morphogenesis. Gordon Research Conference:
Signaling by Adhesion Receptors, poster, Mt. Holyoke, MA.
Sacino, M., Tapanes-Castillo, A., Bixby, J.L. and Lemmon, V.P. (2009) The Hedgehog signaling
pathway regulates cell adhesion molecule mediated neuronal morphogenesis. Society for
Neuroscience Annual Meeting, poster 410.8, Chicago, IL.
Shabazz, F., M'boge, M., Leary, L., Perez, T., Amador, A., Singer, M., Tapanes-Castillo, A.,
Oudega, M.,Plunkett, J.A. (2009) Establishment of a primary brainstem neuronal culture from adult
Danio rerio as a model system for CNS axon regeneration. 18th Annual University of Miami Miller
School of Medicine Neuroscience Research Day, poster, Miami, FL.