Professor Makdisi has written extensively on American and Islamic property law among other subjects. His book on Estates in Land and Future Interests is now in its 7th edition. In 2017 Professor Makdisi completed ten years of study in moral theology with a Ph.D. dissertation on The Object of the Moral Act: Understanding St. Thomas Aquinas through the Work of Steven Long and Martin Rhonheimer. His article on The Islamic Origins of the Common Law, 77 N. Car. L. Rev. 1635 (1999), offers a new theory for connections between Islam and the West.
From 1981-1991, Professor Makdisi was a faculty member at Cleveland-Marshall College of Law, where he also served as Associate Dean from 1988-91. He served as Dean of the University of Tulsa College of Law from 1991-1994, returned to faculty from 1994-96, and then became Dean at Loyola University New Orleans School of Law from 1996-1999. From 1999-2003, Professor Makdisi served as Dean of St. Thomas University School of Law in Miami, Florida, as well as Interim Vice President for Academic Affairs in 2000-2001. In 2003, he returned to faculty where he is now a Professor of Law and teaches Property, Natural Law, Remedies, and Evidence.